We conclude that diabetes status is associated with a small but statistically significant reduction of the whole cortex volume, mainly in the frontal lobe. No group-differences were observed in the occipital lobe or in the anterior cingulate, posterior cingulate, hippocampus, and thalamus. On the other hand, patients with normal awareness did not present significant volume differences compared to controls. Such differences were very similar to those observed between patients with impaired awareness and controls (−7.6%, p = 0.0002 in whole cortex, −9.1%, p = 0.0003 in frontal lobe, −7.8%, p = 0.002 in parietal lobe, and −6.4%, p = 0.019 in temporal lobe). Indeed, compared to the patients with normal awareness of hypoglycemia, patients with impaired awareness had smaller volume of the whole cortex (−7.9%, p = 0.0009), and in particular of the frontal lobe (−9.1%, p = 0.006), parietal lobe (−8.0%, p = 0.015) and temporal lobe (−8.2%, p = 0.009). Similar differences of even larger magnitude were observed among the T1D subjects based on their hypoglycemia awareness status. T1D subjects were found to have slightly smaller volume of the whole cortex as compared to controls (−2.7%, p = 0.016), with the most affected brain region being the frontal lobe (−3.6%, p = 0.024). Our goals were to test whether the gray matter (GM) volumes of selected brain regions were associated with diabetes status as well as with the status of hypoglycemia awareness. The T1D group was further subdivided based on whether subjects had normal, impaired, or indeterminate awareness of hypoglycemia (n = 31, 20, and 1, respectively). New Preview tile screen allows you manually crop or edit cell images.In this study, we retrospectively analyzed the anatomical MRI data acquired from 52 subjects with type 1 diabetes (26M/26F, 36 ± 11 years old, A1C = 7.2 ± 0.9%) and 50 age, sex and BMI frequency-matched non-diabetic controls (25M/25F, 36 ± 14 years old). Or you might need to make sure that a particularly well-liked image is not passed over as a tile for example that Uncle Ernie appears somewhere in your final mosaic. If you don't like an image, substitute it with another matching candidate image! And even more! You might insert custom images as a sort of personal signature, or as a hidden picture riddle (as in a "Where are they?" puzzle book). Mazaika is the ONLY photo mosaic application that allows manual changes to every single tile in the finished mosaic. Note that even in trial version of Mazaika you have no limit on the image database size and you could use as many of your own custom picture tiles as you want - or rather, as you have :-). If you have a digital camera, you can use your own pictures as tiles. You can use even simple icon files (at size 32x32 pixels) to create very impressive mosaic pictures. Using Mazaika you can make professional looking mosaic pictures from almost any kind and type of image files. Besides many small pictures there are some very hi res pictures which you can print as big as A3 or even larger. There are lot more example pictures at gallery section. On the Mazaika page you can see screenshots and few mosaic examples. Here is a samples gallery of these pictures. Mazaika can create pictures made of other pictures. Mazaika is a professional photo mosaic tool.
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